Stadium: Bob Shelton Stadium Round: 1
| NCAA Division I, FCS, Playoffs | 2022/11/19 18:00 | Trinity Tigers v Hardin Simmons Cowboys | L | 14-7 |
| NCAA Division I, FCS, Playoffs | 2022/11/12 19:00 | Texas Lutheran Bulldogs v Hardin Simmons Cowboys | W | 16-45 |
| NCAA Division I, FCS, Playoffs | 2022/11/05 18:00 | Hardin Simmons Cowboys v Austin Kangaroos | W | 31-3 |
| NCAA Division I, FCS, Playoffs | 2022/10/29 18:00 | Hardin Simmons Cowboys v Howard Payne Yellow Jackets | W | 28-19 |
| NCAA Division I, FCS, Playoffs | 2022/10/22 18:00 | Southwestern Pirates v Hardin Simmons Cowboys | W | 0-68 |
| NCAA Division I, FCS, Playoffs | 2022/10/15 18:00 | Hardin Simmons Cowboys v East Texas Baptist Tigers | W | 27-7 |
| NCAA Division I, FCS, Playoffs | 2022/10/08 18:00 | Hardin Simmons Cowboys v Sul Ross State Lobos | W | 70-35 |
| NCAA Division I, FCS, Playoffs | 2022/10/01 21:00 | Mcmurry War Hawks v Hardin Simmons Cowboys | W | 13-45 |
| NCAA Division I, FCS, Playoffs | 2022/11/12 17:00 | Lebanon Valley Flying Dutchmen v Albright Lions | L | 41-24 |
| NCAA Division I, FCS, Playoffs | 2022/11/05 16:00 | Albright Lions v Alvernia Golden Wolves | L | 14-21 |
| NCAA Division I, FCS, Playoffs | 2022/10/29 16:00 | Fdu Florham Devils v Albright Lions | L | 10-2 |
| NCAA Division I, FCS, Playoffs | 2022/10/22 17:00 | Widener Pride v Albright Lions | L | 34-28 |
| NCAA Division I, FCS, Playoffs | 2022/10/15 16:00 | Albright Lions v Kings Monarchs | L | 21-27 |
| NCAA Division I, FCS, Playoffs | 2022/10/01 16:00 | Wilkes Colonels v Albright Lions | L | 27-0 |
| NCAA Division I, FCS, Playoffs | 2022/09/24 16:00 | Albright Lions v Lycoming Warriors | L | 0-45 |
| NCAA Division I, FCS, Playoffs | 2022/09/17 16:00 | Albright Lions v Misericordia Cougars | L | 21-27 |