Stadium: Abel Stadium Round: 1
| NCAA Division I, FCS, Playoffs | 2022/09/10 18:00 | Mayville State Comets v Nebraska Wesleyan Prairie Wolves | L | 55-48 |
| NCAA Division I, FCS, Playoffs | 2023/09/03 00:00 | Austin Kangaroos v Nebraska Wesleyan Prairie Wolves | W | 7-19 |
| NCAA Division I, FCS, Playoffs | 2022/11/12 18:00 | Luther Norse v Nebraska Wesleyan Prairie Wolves | L | 35-28 |
| NCAA Division I, FCS, Playoffs | 2022/11/05 18:00 | Nebraska Wesleyan Prairie Wolves v Coe Kohawks | L | 14-34 |
| NCAA Division I, FCS, Playoffs | 2022/10/29 18:00 | Simpson Storm v Nebraska Wesleyan Prairie Wolves | L | 74-41 |
| NCAA Division I, FCS, Playoffs | 2022/10/22 21:30 | Nebraska Wesleyan Prairie Wolves v Buena Vista Beavers | L | 25-42 |
| NCAA Division I, FCS, Playoffs | 2022/10/15 18:30 | Wartburg Knights v Nebraska Wesleyan Prairie Wolves | L | 65-0 |
| NCAA Division I, FCS, Playoffs | 2022/10/01 18:00 | Nebraska Wesleyan Prairie Wolves v Central Dutch | L | 0-58 |
| NCAA Division I, FCS, Playoffs | 2022/09/24 18:00 | Loras Duhawks v Nebraska Wesleyan Prairie Wolves | L | 49-31 |
| NCAA Division I, FCS, Playoffs | 2022/09/10 18:00 | Mayville State Comets v Nebraska Wesleyan Prairie Wolves | W | 55-48 |
| NCAA Division I, FCS, Playoffs | 2022/09/03 23:00 | UW–Stevens Point v Mayville State Comets | W | 24-31 |
| NCAA Division I, FCS, Playoffs | 2021/09/11 23:00 | South Dakota Mines Hardrockers v Mayville State Comets | L | 52-7 |
| NCAA Division I, FCS, Playoffs | 2021/09/04 18:00 | Mayville State Comets v UW–Stevens Point | L | 14-31 |
| NCAA Division I, FCS, Playoffs | 2019/09/21 17:00 | Merrimack Warriors v Mayville State Comets | L | 76-7 |
| NCAA Division I, FCS, Playoffs | 2019/09/07 17:00 | Saint Scholastica v Mayville State Comets | L | 42-35 |
| NCAA Division I, FCS, Playoffs | 2018/09/08 18:00 | Mayville State Comets v Saint Scholastica | W | 33-29 |