Stadium: Carl W. Burt Memorial Stadium Round: 1
| NCAA Division I, FCS, Playoffs | 2022/09/17 18:00 | Greenville Panthers v Manchester Spartans | L | 49-22 |
| NCAA Division I, FCS, Playoffs | 2023/09/09 20:00 | Manchester Spartans v Alma College Scots | L | 0-68 |
| NCAA Division I, FCS, Playoffs | 2023/09/02 22:00 | Manchester Spartans v North Park Vikings | L | 0-27 |
| NCAA Division I, FCS, Playoffs | 2022/11/12 18:30 | Anderson Ravens v Manchester Spartans | L | 19-12 |
| NCAA Division I, FCS, Playoffs | 2022/11/05 17:30 | Defiance Yellow Jackets v Manchester Spartans | L | 24-21 |
| NCAA Division I, FCS, Playoffs | 2022/10/29 17:30 | Manchester Spartans v Franklin College Grizzlies | L | 6-24 |
| NCAA Division I, FCS, Playoffs | 2022/10/22 17:30 | Manchester Spartans v Bluffton Beavers | L | 44-46 |
| NCAA Division I, FCS, Playoffs | 2022/10/15 17:30 | Manchester Spartans v Hanover Panthers | L | 20-51 |
| NCAA Division I, FCS, Playoffs | 2022/10/08 18:00 | Rose Hulman Engineers v Manchester Spartans | L | 48-14 |
| NCAA Division I, FCS, Playoffs | 2023/09/09 17:00 | Greenville Panthers v Eureka Red Devils | L | 14-23 |
| NCAA Division I, FCS, Playoffs | 2023/09/02 18:00 | Concordia Chicago Cougars v Greenville Panthers | W | 14-41 |
| NCAA Division I, FCS, Playoffs | 2022/11/12 18:00 | Minnesota Morris Cougars v Greenville Panthers | W | 25-43 |
| NCAA Division I, FCS, Playoffs | 2022/11/05 17:00 | Greenville Panthers v Finlandia Lions | W | 45-7 |
| NCAA Division I, FCS, Playoffs | 2022/10/29 20:00 | Crown Storm v Greenville Panthers | W | 6-48 |
| NCAA Division I, FCS, Playoffs | 2022/10/15 18:00 | Greenville Panthers v Westminster Blue Jays | W | 52-0 |
| NCAA Division I, FCS, Playoffs | 2022/10/08 17:00 | Northwestern Eagles v Greenville Panthers | L | 41-35 |
| NCAA Division I, FCS, Playoffs | 2022/10/01 17:00 | Greenville Panthers v Martin Luther Knights | W | 30-27 |